Innovation/Impact: We describe the web-based QA infrastructure under development and in use within our paperless radiation oncology clinic. Our framework comprises a centralized web-server that facilitates simultaneous and seamless access to multiple databases within the clinic. All activities, including treatment planning, patient appointments and machine quality control/maintenance, are accessible via a single internal webpage with various software tools and metrics employed for QA and monitoring. We believe that our framework is representative of the direction in which modern radiation oncology departments are moving; namely paperless operation with centralized data access for patient-specific QA and statistical process control.