Bone is one of the most common sites for cancer to metastasize to. Early diagnosis and treatment of bone metastases (BM) can help improve the quality of life of cancer patients and treatment outcomes. Radiotherapy treatment planning for BM is often based on a patient’s simulation CT scans alone without using diagnostic CT or PET images. However, accurate detection of metastases is difficult when using a simulation CT alone. The objective of this study is to investigate the feasibility of building a simulation CT based radiomics model to identify spinal BM.